abstract：BACKGROUND:The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets for neuroprotection against chronic inflammation. METHODS:Surface immunocytochemistry directly vis...

journal_title：Journal of neuroinflammation

authors： Lee PR,Johnson TP,Gnanapavan S,Giovannoni G,Wang T,Steiner JP,Medynets M,Vaal MJ,Gartner V,Nath A

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Antibodies with specificity for myelin oligodendrocyte glycoprotein (MOG) are implicated in multiple sclerosis and related diseases. The pathogenic importance of anti-MOG antibody in primary demyelinating pathology remains poorly characterized. OBJECTIVE:The objective of this study is to investigate whether...

journal_title：Journal of neuroinflammation

authors： Berg CT,Khorooshi R,Asgari N,Owens T

更新日期：2017-06-24 00:00:00

abstract：BACKGROUND:Chronic microglia-mediated inflammation and oxidative stress are well-characterized underlying factors in neurodegenerative disease, whereby reactive inflammatory microglia enhance ROS production and impact neuronal integrity. Recently, it has been shown that during chronic inflammation, neuronal integrity i...

journal_title：Journal of neuroinflammation

authors： Benusa SD,George NM,Sword BA,DeVries GH,Dupree JL

更新日期：2017-06-08 00:00:00

abstract：BACKGROUND:Increasing evidence supports a key role for inflammation in the neurodegenerative process of familial amyloidotic polyneuropathy (FAP). While there seems to be an overactivation of the neuronal interleukin-1 signaling pathway, the immune response is apparently compromised in FAP. Accordingly, little immune c...

journal_title：Journal of neuroinflammation

authors： Gonçalves NP,Moreira J,Martins D,Vieira P,Obici L,Merlini G,Saraiva M,Saraiva MJ

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrPC (PRNP Ter/Ter) provides a novel model for studying PrPC physiology. M...

journal_title：Journal of neuroinflammation

authors： Salvesen Ø,Reiten MR,Espenes A,Bakkebø MK,Tranulis MA,Ersdal C

更新日期：2017-05-22 00:00:00

abstract：BACKGROUND:Opioid receptors are known to control neurotransmission of various peptidergic neurons, but their potential role in regulation of microglia and neuronal cell communications is unknown. We investigated the role of mu-opioid receptors (MOR) and delta-opioid receptors (DOR) on microglia in the regulation of apo...

journal_title：Journal of neuroinflammation

authors： Shrivastava P,Cabrera MA,Chastain LG,Boyadjieva NI,Jabbar S,Franklin T,Sarkar DK

更新日期：2017-04-14 00:00:00

abstract：BACKGROUND:MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs and IL-1 receptor and regulates innate immune response. However, it was not clear whether and how MyD88 and related signaling pathways in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH) are involved in neuropathic pain. ME...

journal_title：Journal of neuroinflammation

authors： Liu F,Wang Z,Qiu Y,Wei M,Li C,Xie Y,Shen L,Huang Y,Ma C

更新日期：2017-03-31 00:00:00

abstract：BACKGROUND:Upregulated levels of 18-kDa translocator proteins (TSPO) and type 2 endocannabinoid receptors (CB2) are considered to reflect different aspects of microglia-related neuroinflammatory responses in the brain. Relative to the increase in the TSPO expression that occurs slightly later during neuroinflammation i...

journal_title：Journal of neuroinflammation

authors： Hosoya T,Fukumoto D,Kakiuchi T,Nishiyama S,Yamamoto S,Ohba H,Tsukada H,Ueki T,Sato K,Ouchi Y

更新日期：2017-03-29 00:00:00

abstract：BACKGROUND:Local and systemic inflammatory responses are initiated early after traumatic brain injury (TBI), and may play a key role in the secondary injury processes resulting in neuronal loss and neurological deficits. However, the mechanisms responsible for the rapid expansion of neuroinflammation and its long-term ...

journal_title：Journal of neuroinflammation

authors： Kumar A,Stoica BA,Loane DJ,Yang M,Abulwerdi G,Khan N,Kumar A,Thom SR,Faden AI

更新日期：2017-03-15 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is a devastating neurological condition and a frequent cause of permanent disability. Posttraumatic inflammation and brain edema formation, two pathological key events contributing to secondary brain injury, are mediated by the contact-kinin system. Activation of this pathway in ...

journal_title：Journal of neuroinflammation

authors： Hopp S,Nolte MW,Stetter C,Kleinschnitz C,Sirén AL,Albert-Weissenberger C

更新日期：2017-02-20 00:00:00

abstract：BACKGROUND:Endoplasmic reticulum (ER) stress is a hallmark of neurodegenerative diseases such as multiple sclerosis (MS). However, this physiological mechanism has multiple manifestations that range from impaired clearance of unfolded proteins to altered mitochondrial dynamics and apoptosis. While connections between t...

journal_title：Journal of neuroinflammation

authors： Haile Y,Deng X,Ortiz-Sandoval C,Tahbaz N,Janowicz A,Lu JQ,Kerr BJ,Gutowski NJ,Holley JE,Eggleton P,Giuliani F,Simmen T

更新日期：2017-01-23 00:00:00

abstract：:Stroke is one of the leading causes of death worldwide. A strong inflammatory response characterized by activation and release of cytokines, chemokines, adhesion molecules, and proteolytic enzymes contributes to brain damage following stroke. Stroke outcomes are worse among diabetics, resulting in increased mortality ...

journal_title：Journal of neuroinflammation

authors： Shukla V,Shakya AK,Perez-Pinzon MA,Dave KR

更新日期：2017-01-23 00:00:00

abstract：BACKGROUND:Epilepsy is a common and debilitating consequence of traumatic brain injury (TBI). Seizures contribute to progressive neurodegeneration and poor functional and psychosocial outcomes for TBI survivors, and epilepsy after TBI is often resistant to existing anti-epileptic drugs. The development of post-traumati...

journal_title：Journal of neuroinflammation

authors： Webster KM,Sun M,Crack P,O'Brien TJ,Shultz SR,Semple BD

更新日期：2017-01-13 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability. Accumulating evidence points to a key role for neuroinflammation, oxidative stress, and excitotoxicity in this degenerative process. System xc- or...

journal_title：Journal of neuroinflammation

authors： Merckx E,Albertini G,Paterka M,Jensen C,Albrecht P,Dietrich M,Van Liefferinge J,Bentea E,Verbruggen L,Demuyser T,Deneyer L,Lewerenz J,van Loo G,De Keyser J,Sato H,Maher P,Methner A,Massie A

更新日期：2017-01-13 00:00:00

abstract：BACKGROUND:Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related to the severity of the pro-inflammatory response in the subarachnoid space. The complement system, wh...

journal_title：Journal of neuroinflammation

authors： Kasanmoentalib ES,Valls Seron M,Ferwerda B,Tanck MW,Zwinderman AH,Baas F,van der Ende A,Schwaeble WJ,Brouwer MC,van de Beek D

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:The mechanism of leukocyte transendothelial migration (TEM) across the highly restrictive blood-brain barrier (BBB) remains enigmatic, with paracellular TEM thought to require leukocytes to somehow navigate the obstructive endothelial tight junctions (TJs). Transient interactions between TJ proteins on the r...

journal_title：Journal of neuroinflammation

authors： Paul D,Baena V,Ge S,Jiang X,Jellison ER,Kiprono T,Agalliu D,Pachter JS

更新日期：2016-11-16 00:00:00

abstract：BACKGROUND:A key feature of the inflammatory response after cerebral ischemia is the brain infiltration of blood monocytes. There are two main monocyte subsets in the mouse blood: CCR2+Ly6Chi "inflammatory" monocytes involved in acute inflammation, and CX3CR1+Ly6Clo "patrolling" monocytes, which may play a role in repa...

journal_title：Journal of neuroinflammation

authors： Garcia-Bonilla L,Faraco G,Moore J,Murphy M,Racchumi G,Srinivasan J,Brea D,Iadecola C,Anrather J

更新日期：2016-11-04 00:00:00

abstract：BACKGROUND:Discoveries that microglia-mediated neuroinflammation is involved in the pathological process of depression provided a new strategy for novel antidepressant therapy. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor regulating inflammation and microglial polarization and, therefore, ...

journal_title：Journal of neuroinflammation

authors： Zhao Q,Wu X,Yan S,Xie X,Fan Y,Zhang J,Peng C,You Z

更新日期：2016-10-04 00:00:00

abstract：BACKGROUND:Synaptodendritic damage is a pathological hallmark of HIV-associated neurocognitive disorders, and HIV-1 Tat protein is known to cause such injury in the central nervous system. In this study, we aimed to determine the molecular mechanisms of Tat-induced neurite shortening, specifically the roles of miR-132,...

journal_title：Journal of neuroinflammation

authors： Rahimian P,He JJ

更新日期：2016-09-15 00:00:00

abstract：BACKGROUND:Chorioamnionitis is associated with an increased risk of brain injury in preterm neonates. Inflammatory changes in brain could underlie this injury. Here, we evaluated whether neuroinflammation is induced by chorioamnionitis in a clinically relevant model. METHODS:Rhesus macaque fetuses were exposed to eith...

journal_title：Journal of neuroinflammation

authors： Schmidt AF,Kannan PS,Chougnet CA,Danzer SC,Miller LA,Jobe AH,Kallapur SG

更新日期：2016-09-06 00:00:00

abstract：BACKGROUND:Harnessing the actions of the resolvin pathways has the potential for the treatment of a wide range of conditions associated with overt inflammatory signalling. Aspirin-triggered resolvin D1 (AT-RvD1) has robust analgesic effects in behavioural models of pain; however, the potential underlying spinal neuroph...

journal_title：Journal of neuroinflammation

authors： Meesawatsom P,Burston J,Hathway G,Bennett A,Chapman V

更新日期：2016-09-02 00:00:00

abstract：BACKGROUND:Although electroconvulsive therapy (ECT) is regarded as one of the efficient treatments for intractable psychiatric disorders, the mechanism of therapeutic action remains unclear. Recently, many studies indicate that ECT affects the immune-related cells, such as microglia, astrocytes, and lymphocytes. Moreov...

journal_title：Journal of neuroinflammation

authors： Limoa E,Hashioka S,Miyaoka T,Tsuchie K,Arauchi R,Azis IA,Wake R,Hayashida M,Araki T,Furuya M,Liaury K,Tanra AJ,Horiguchi J

更新日期：2016-09-02 00:00:00

abstract：BACKGROUND:Tick-borne encephalitis virus (TBEV) is one of the most important flaviviruses that targets the central nervous system (CNS) and causes encephalitides in humans. Although neuroinflammatory mechanisms may contribute to brain tissue destruction, the induction pathways and potential roles of specific chemokines...

journal_title：Journal of neuroinflammation

authors： Zhang X,Zheng Z,Liu X,Shu B,Mao P,Bai B,Hu Q,Luo M,Ma X,Cui Z,Wang H

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:Complement activation via the lectin activation pathway (LP) has been identified as the key mechanism behind post-ischemic tissue inflammation causing ischemia-reperfusion injury (IRI) which can significantly impact the clinical outcome of ischemic disease. This work defines the contributions of each of the ...

journal_title：Journal of neuroinflammation

authors： Orsini F,Chrysanthou E,Dudler T,Cummings WJ,Takahashi M,Fujita T,Demopulos G,De Simoni MG,Schwaeble W

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:The neutrophil to lymphocyte ratio (NLR) has been shown to predict short- and long-term outcomes in ischemic stroke patients. We sought to explore the temporal profile of the plasma NLR in stroke patients treated with intravenous thrombolysis (IVT) and its relationship with intracranial bleeding complication...

journal_title：Journal of neuroinflammation

authors： Guo Z,Yu S,Xiao L,Chen X,Ye R,Zheng P,Dai Q,Sun W,Zhou C,Wang S,Zhu W,Liu X

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:The proteasome is a multisubunit enzyme complex involved in protein degradation, which is essential for many cellular processes. During inflammation, the constitutive subunits are replaced by their inducible counterparts, resulting in the formation of the immunoproteasome. METHODS:We investigated the expres...

journal_title：Journal of neuroinflammation

authors： van Scheppingen J,Broekaart DW,Scholl T,Zuidberg MR,Anink JJ,Spliet WG,van Rijen PC,Czech T,Hainfellner JA,Feucht M,Mühlebner A,van Vliet EA,Aronica E

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Obesity and its associated disorders are becoming a major health issue in many countries. The resulting low-grade inflammation not only affects the periphery but also the central nervous system. We set out to study, in a time-dependent manner, the effects of a high-fat diet on different regions of the centra...

journal_title：Journal of neuroinflammation

authors： Guillemot-Legris O,Masquelier J,Everard A,Cani PD,Alhouayek M,Muccioli GG

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Acute traumatic brain injury (TBI) represents one of major causes of mortality and disability in the USA. Neuroinflammation has been regarded both beneficial and detrimental, probably in a time-dependent fashion. METHODS:To address a role for neuroinflammation in brain injury, C57BL/6 mice were subjected to...

journal_title：Journal of neuroinflammation

authors： Dong T,Zhi L,Bhayana B,Wu MX

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:Synucleinopathies comprise a group of neurodegenerative diseases associated with abnormal accumulation of α-synuclein. One of the key factors that contribute to the progression of synucleinopathies is neuroinflammation. However, the role of lymphocytes in synucleinopathies like Parkinson's disease (PD) remai...

journal_title：Journal of neuroinflammation

authors： Sommer A,Fadler T,Dorfmeister E,Hoffmann AC,Xiang W,Winner B,Prots I

更新日期：2016-06-30 00:00:00

abstract：BACKGROUND:The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining patholog...

journal_title：Journal of neuroinflammation

authors： Watkins LM,Neal JW,Loveless S,Michailidou I,Ramaglia V,Rees MI,Reynolds R,Robertson NP,Morgan BP,Howell OW

更新日期：2016-06-22 00:00:00

abstract：BACKGROUND:Demyelination and remyelination are common pathological processes in many neurological disorders, including multiple sclerosis (MS). Clinical evidence suggests extensive involvement of the thalamocortical (TC) system in patients suffering from MS. METHODS:Using murine brain slices of the primary auditory co...

journal_title：Journal of neuroinflammation

authors： Ghaffarian N,Mesgari M,Cerina M,Göbel K,Budde T,Speckmann EJ,Meuth SG,Gorji A

更新日期：2016-06-22 00:00:00

abstract：BACKGROUND:The early dysfunction and subsequent recovery after stroke, characterized by the destruction and remodeling of connective pathways between cortex and subcortical regions, is associated with neuroinflammation. As major components of the inflammatory process, reactive astrocytes have double-edged effects on pa...

journal_title：Journal of neuroinflammation

authors： Hao XZ,Yin LK,Zhang XX,Tian JQ,Li CC,Feng XY,Jiang M,Yang YM

更新日期：2016-06-18 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is frequently associated with gastrointestinal (GI) symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying such disorders are still largely unknown, although the occurrence of a bowel inflammatory condition has been hypothesized. This study examined t...

journal_title：Journal of neuroinflammation

authors： Pellegrini C,Fornai M,Colucci R,Tirotta E,Blandini F,Levandis G,Cerri S,Segnani C,Ippolito C,Bernardini N,Cseri K,Blandizzi C,Haskó G,Antonioli L

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are pleiotropic signaling molecules with a broad range of physiological functions. Targeting the S1P1 receptor on lymphocytes with the immunomodulatory drug fingolimod has proven effective in the treatment of multiple scleros...

journal_title：Journal of neuroinflammation

authors： Szepanowski F,Derksen A,Steiner I,Meyer Zu Hörste G,Daldrup T,Hartung HP,Kieseier BC

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Elevated levels of oncostatin M (OSM), an interleukin-6 cytokine family member, have been observed in HIV-1-associated neurocognitive disorders (HAND) and Alzheimer's disease. However, the function of OSM in these disease conditions is unclear. Since deficient glutamate uptake by astrocytes is instrumental i...

journal_title：Journal of neuroinflammation

authors： Moidunny S,Matos M,Wesseling E,Banerjee S,Volsky DJ,Cunha RA,Agostinho P,Boddeke HW,Roy S

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Oxidative stress plays an important and causal role in the mechanisms by which ischemia/reperfusion (I/R) injury increases brain damage after stroke. Accordingly, reducing oxidative stress has been proposed as a therapeutic strategy for limiting damage in the brain after stroke. Myeloperoxidase (MPO) is a hi...

journal_title：Journal of neuroinflammation

authors： Yu G,Liang Y,Huang Z,Jones DW,Pritchard KA Jr,Zhang H

更新日期：2016-05-24 00:00:00

abstract：BACKGROUND:Peripheral nerve injury results in retrograde cell body-related changes in the spinal motoneurons that will contribute to the regenerative response of their axons. Successful functional recovery also depends on molecular events mediated by innate immune response during Wallerian degeneration in the nerve mic...

journal_title：Journal of neuroinflammation

authors： Freria CM,Bernardes D,Almeida GL,Simões GF,Barbosa GO,Oliveira AL

更新日期：2016-05-24 00:00:00

abstract：BACKGROUND:Obesity can lead to cognitive dysfunction including poor performance in memory tasks. However, poor memory is not seen in all obese humans and takes several months to develop in animal models, indicating the adult brain is relatively resistant to obesity's cognitive effects. We have seen that, in the rat, ov...

journal_title：Journal of neuroinflammation

authors： De Luca SN,Ziko I,Sominsky L,Nguyen JC,Dinan T,Miller AA,Jenkins TA,Spencer SJ

更新日期：2016-05-18 00:00:00

abstract：BACKGROUND:In schizophrenia, genetic background may provide a substrate for intrinsic maldevelopment of the brain through environmental influences, by recruiting neurotrophic factors and cytokines, to trigger the changes that lead to impaired neuronal functions. Cytokines being the key regulators of immune/inflammatory...

journal_title：Journal of neuroinflammation

authors： Srinivas L,Vellichirammal NN,Alex AM,Nair C,Nair IV,Banerjee M

更新日期：2016-05-13 00:00:00

abstract：BACKGROUND:Neuroinflammation in utero may contribute to brain injury resulting in life-long neurological disabilities. The pivotal role of the efferent cholinergic anti-inflammatory pathway (CAP) in controlling inflammation, e.g., by inhibiting the HMGB1 release, via the macrophages' α7 nicotinic acetylcholine receptor...

journal_title：Journal of neuroinflammation

authors： Frasch MG,Szynkaruk M,Prout AP,Nygard K,Cao M,Veldhuizen R,Hammond R,Richardson BS

更新日期：2016-05-10 00:00:00